Plasmalogen Therapy

Prevention & Longevity

Plasmalogen Therapy

Prevention & Longevity

Prodrome Scan & Plasmalogens

The Prodrome Scan is a blood test developed by Dr. Dayan Goodenowe.

Almost all results relate to various lipids in the body, including plasmalogens.

The sections below explain the meaning of each result and ways to correct deficiencies.

We hope you understand how unique and important these results are, for there is not other lab test of its kind.

The results are a snapshot of cell membrane health, fatty acids related to our diet, our mitochondrial function, cholesterol transport, plasmalogen levels and peroxisomal function.

We acknowledge the devotion and research of Dr. Dayan Goodenowe over the last 20 years.

Without him, we, as clinicians, would not possess this vital information to help our clients.

Membrane Phospholipids

The first section covers membrane phospholipids, the lipids or fats which make up our cell membranes.

These are the most abundant and most important lipids in the body.

Our cell membranes are about 50% cholesterol and 50% phospholipids.

The two most important phospholipids are ethanolamine and choline.

The ethanolamine lipids come from our diet while the choline lipids are only partly from our diet, most being made from ethanolamines.

Plasmalogens are required for proper membrane and nerve function.  Low plasmalogens are associated with Alzheimer’s Disease, dementia, Parkinson’s, Multiple Sclerosis, and some cancers. 

You can see how important these results are, to know whether or not a person’s plasmalogen levels are optimal, or if they need to improve their levels through supplementation.

Based on these results, recommendations could include dietary changes and supplements such as Prodrome Neuro, phospho-ethanolamine, phosphatidyl choline and serine, DHA and alpha GPC (choline).

Dietary Fatty Acids

Section 5 of the Prodrome Scan covers the Omega 3, 6 and 9 fatty acids which come from both our diet and the body’s synthesis.

One result, Arachidonic Acid (AA) is a marker for inflammation and cardiovascular diseases.

An increase in AA can be for several reasons, the main one being too much Omega 6 oils and too little Omega 3 oils.

Reducing Omega 6 oils such as corn, soy, safflower and sunflower oils is important.

Ingesting DHA Omega 3 fish oils is recommended.

Both Prodrome Neuro and Prodrome Glia, developed by Dr. Goodenowe, are often recommended to improve imbalances in these fatty acids.

Gastrointestinal Tract Acids

GTAs are fatty acids made by beneficial gut microbes, and absorbed into the blood supply.

They have anti-inflammatory and anti-cancer properties.

People with decreased GTA levels have an increased risk of colorectal and pancreatic cancer, and a number of inflammatory diseases.

Dr. Goodenowe’s lab was the first to discover these fatty acids.

The supplement Prodrome GTA was designed to correct low levels of GTA.

It contains highly concentrated BDMC (Bisdemethoxycurcumin), a naturally occurring curcuminoid, which decreases inflammation and helps to trigger apoptosis (death) of tumors via mitochondria modulation.

Methyltransferase Choline System

Section 8 of the Scan is used to evaluate the methyltransferase system and choline availability and usage.

This system allows for choline synthesis (cell membranes, neurotransmitters and plasmalogen synthesis) and creatine synthesis (muscle building and maintenance).

Various imbalances in this section point towards increased risk for dementia, metabolic syndrome, cardiovascular and neurological diseases, and all-cause mortality.

Levels greater than 10 for homocysteine warrant supplementing with choline and/or creatine, N-Acetyl Cysteine (NAC), B12, B6, and folic acid in the methyl-tetrahydrofolate form.

Low levels of phosphatidylethanolamines (8a-PEs) in relation to phosphatidylcholine (8b-PCs) indicate insufficient dietary intake of ethanolamine.

Often NAC supplementation is suggested with methyltransferase issues to ensure healthy glutathione levels.

Mitochondrial Function

The primary purpose of this section of the Prodrome Scan is to evaluate the overall functionality of mitochondria.

Mitochondria a tiny organelles found in every cell of the body, except red blood cells.  The number of mitochondria in cells range from a few (fat cells) to thousands (brain, heart and liver).

Their primary action is to produce energy, to drive or power the function of the cell in which they reside.

They are the most important organelle in the human body.

The ideal profile is having Linoleic Acid (9a) greater than Arachidonic Acid (9b), and this greater than Adrenic Acid (9c).

If Adrenic Acid is greater than Arachidonic Acid, mitochondrial leakage is present.  For this, supplementation with Ubiquinol, Acetyl L-Carnitine, NAC, Alpha Lipoic Acid and NAD (nicotinamide adenine dinucleotide) are needed.

Inflammation is the primary source of mitochondrial stress.

Lifestyle interventions such as intermittent fasting, lowering of high glycemic foods, and natural anti-inflammatory supplements such as Prodrome Glia and Prodrome GTA are helpful.

Peroxisomal Function

The primary purpose of this section is to evaluate peroxisomal function and output.

Peroxisomes and mitochondria are physically distinct organelles that are in all cells of the body except red blood cells.

The primary purpose of peroxisomes is to regulate and maintain consistent mitochondrial function.

Peroxisomes are where plamalogens, DHA and EPA are made.

Impaired peroxisome function due to aging or toxicity results in decreased biosynthesis of plasmalogens, DHA and increased levels of pro-inflammatory very long chain fatty acids.

This decreased biosynthesis of plasmalogens also creates an overload and stress on mitochondria, resulting in cells switching to anaerobic, pro-cancer, metabolism.

Obviously, for health and longevity, we need to maximize both mitochondrial and peroxisomal function.

Cholesterol Transport

The primary purpose of this section is to evaluate the overall cholesterol regulation system.

Cholesterol is one of the most important lipids in the body.

Most of the body’s cholesterol is in the outer plasma membrane of all the cells.

The body has very sophisticated transport and regulation systems for cholesterol.

The bulk of the circulating cholesterol in the body is derived from liver synthesis, about 75%, while only 25% is derived from our diet.

Cholesterol is ‘packaged’ along with triglycerides on very low-density lipoproteins (VLDL).

VLDLs are then converted to LDLs, or low-density lipoproteins, and are the main circulating source of cholesterol.

All cells of the body have LDL receptors on their membranes, allowing them to capture and absorb LDL-cholesterol.

LDL levels are an indicator of cellular cholesterol demand.  High levels mean low demand while low levels mean high demand.

Low HDL (high-density lipoproteins) levels indicate impaired cholesterol export and high membrane levels, while high HDLs are associated with healthy export and low membrane cholesterol.

HDL levels in the 60-90 range and total cholesterol in the 200-250 range are ideal.

Prodrome Scan Blood Test

The Prodrome Scan requires a fasting blood draw, so no food or drink for 12 hours before, but water is OK.

Some people with various conditions such as Alzheimer’s, dementia, Parkinson’s, Multiple Sclerosis and other neurological conditions ask, ‘Can I just take the supplements Prodrome Neuro and Prodrome Glia without doing the blood test?”

Yes you can, but there are many results which offer a wider point of view which indicate deficiencies and the possible need for other supplements.

Results indicating systemic inflammation point towards both supplementation and deeper investigation as to why.

Results indicating mitochondria and peroxisome dysfunction also lead us into deeper investigation, likely requiring specific supplements and intravenous therapies to increase mitochondrial function.

On the Prodrome Science site, this lab test kit sells for $499. 

We offer the kit for $425 which includes the blood draw.

The evaluation of results takes about 45 to 60 minutes and there is a charge for this review.

Prodrome Scan & Plasmalogens

The Prodrome Scan is a blood test developed by Dr. Dayan Goodenowe.

Almost all results relate to various lipids in the body, including plasmalogens.

The sections below explain the meaning of each result and ways to correct deficiencies.

We hope you understand how unique and important these results are, for there is not other lab test of its kind.

The results are a snapshot of cell membrane health, fatty acids related to our diet, our mitochondrial function, cholesterol transport, plasmalogen levels and peroxisomal function.

We acknowledge the devotion and research of Dr. Dayan Goodenowe over the last 20 years.

Without him, we, as clinicians, would not possess this vital information to help our clients.

Membrane Phospholipids

The first section covers membrane phospholipids, the lipids or fats which make up our cell membranes.

These are the most abundant and most important lipids in the body.

Our cell membranes are about 50% cholesterol and 50% phospholipids.

The two most important phospholipids are ethanolamine and choline.

The ethanolamine lipids come from our diet while the choline lipids are only partly from our diet, most being made from ethanolamines.

Plasmalogens are required for proper membrane and nerve function.  Low plasmalogens are associated with Alzheimer’s Disease, dementia, Parkinson’s, Multiple Sclerosis, and some cancers. 

You can see how important these results are, to know whether or not a person’s plasmalogen levels are optimal, or if they need to improve their levels through supplementation.

Based on these results, recommendations could include dietary changes and supplements such as Prodrome Neuro, phospho-ethanolamine, phosphatidyl choline and serine, DHA and alpha GPC (choline).

Dietary Fatty Acids

Section 5 of the Prodrome Scan covers the Omega 3, 6 and 9 fatty acids which come from both our diet and the body’s synthesis.

One result, Arachidonic Acid (AA) is a marker for inflammation and cardiovascular diseases.

An increase in AA can be for several reasons, the main one being too much Omega 6 oils and too little Omega 3 oils.

Reducing Omega 6 oils such as corn, soy, safflower and sunflower oils is important.

Ingesting DHA Omega 3 fish oils is recommended.

Both Prodrome Neuro and Prodrome Glia, developed by Dr. Goodenowe, are often recommended to improve imbalances in these fatty acids.

Gastrointestinal Tract Acids

GTAs are fatty acids made by beneficial gut microbes, and absorbed into the blood supply.

They have anti-inflammatory and anti-cancer properties.

People with decreased GTA levels have an increased risk of colorectal and pancreatic cancer, and a number of inflammatory diseases.

Dr. Goodenowe’s lab was the first to discover these fatty acids.

The supplement Prodrome GTA was designed to correct low levels of GTA.

It contains highly concentrated BDMC (Bisdemethoxycurcumin), a naturally occurring curcuminoid, which decreases inflammation and helps to trigger apoptosis (death) of tumors via mitochondria modulation.

Methyltransferase Choline System

Section 8 of the Scan is used to evaluate the methyltransferase system and choline availability and usage.

This system allows for choline synthesis (cell membranes, neurotransmitters and plasmalogen synthesis) and creatine synthesis (muscle building and maintenance).

Various imbalances in this section point towards increased risk for dementia, metabolic syndrome, cardiovascular and neurological diseases, and all-cause mortality.

Levels greater than 10 for homocysteine warrant supplementing with choline and/or creatine, N-Acetyl Cysteine (NAC), B12, B6, and folic acid in the methyl-tetrahydrofolate form.

Low levels of phosphatidylethanolamines (8a-PEs) in relation to phosphatidylcholine (8b-PCs) indicate insufficient dietary intake of ethanolamine.

Often NAC supplementation is suggested with methyltransferase issues to ensure healthy glutathione levels.

Mitochondrial Function

The primary purpose of this section of the Prodrome Scan is to evaluate the overall functionality of mitochondria.

Mitochondria a tiny organelles found in every cell of the body, except red blood cells.  The number of mitochondria in cells range from a few (fat cells) to thousands (brain, heart and liver).

Their primary action is to produce energy, to drive or power the function of the cell in which they reside.

They are the most important organelle in the human body.

The ideal profile is having Linoleic Acid (9a) greater than Arachidonic Acid (9b), and this greater than Adrenic Acid (9c).

If Adrenic Acid is greater than Arachidonic Acid, mitochondrial leakage is present.  For this, supplementation with Ubiquinol, Acetyl L-Carnitine, NAC, Alpha Lipoic Acid and NAD (nicotinamide adenine dinucleotide) are needed.

Inflammation is the primary source of mitochondrial stress.

Lifestyle interventions such as intermittent fasting, lowering of high glycemic foods, and natural anti-inflammatory supplements such as Prodrome Glia and Prodrome GTA are helpful.

Peroxisomal Function

The primary purpose of this section is to evaluate peroxisomal function and output.

Peroxisomes and mitochondria are physically distinct organelles that are in all cells of the body except red blood cells.

The primary purpose of peroxisomes is to regulate and maintain consistent mitochondrial function.

Peroxisomes are where plamalogens, DHA and EPA are made.

Impaired peroxisome function due to aging or toxicity results in decreased biosynthesis of plasmalogens, DHA and increased levels of pro-inflammatory very long chain fatty acids.

This decreased biosynthesis of plasmalogens also creates an overload and stress on mitochondria, resulting in cells switching to anaerobic, pro-cancer, metabolism.

Obviously, for health and longevity, we need to maximize both mitochondrial and peroxisomal function.

Cholesterol Transport

The primary purpose of this section is to evaluate the overall cholesterol regulation system.

Cholesterol is one of the most important lipids in the body.

Most of the body’s cholesterol is in the outer plasma membrane of all the cells.

The body has very sophisticated transport and regulation systems for cholesterol.

The bulk of the circulating cholesterol in the body is derived from liver synthesis, about 75%, while only 25% is derived from our diet.

Cholesterol is ‘packaged’ along with triglycerides on very low-density lipoproteins (VLDL).

VLDLs are then converted to LDLs, or low-density lipoproteins, and are the main circulating source of cholesterol.

All cells of the body have LDL receptors on their membranes, allowing them to capture and absorb LDL-cholesterol.

LDL levels are an indicator of cellular cholesterol demand.  High levels mean low demand while low levels mean high demand.

Low HDL (high-density lipoproteins) levels indicate impaired cholesterol export and high membrane levels, while high HDLs are associated with healthy export and low membrane cholesterol.

HDL levels in the 60-90 range and total cholesterol in the 200-250 range are ideal.

Prodrome Scan Blood Test

The Prodrome Scan requires a fasting blood draw, so no food or drink for 12 hours before, but water is OK.

Some people with various conditions such as Alzheimer’s, dementia, Parkinson’s, Multiple Sclerosis and other neurological conditions ask, ‘Can I just take the supplements Prodrome Neuro and Prodrome Glia without doing the blood test?”

Yes you can, but there are many results which offer a wider point of view which indicate deficiencies and the possible need for other supplements.

Results indicating systemic inflammation point towards both supplementation and deeper investigation as to why.

Results indicating mitochondria and peroxisome dysfunction also lead us into deeper investigation, likely requiring specific supplements and intravenous therapies to increase mitochondrial function.

On the Prodrome Science site, this lab test kit sells for $499. 

We offer the kit for $425 which includes the blood draw.

The evaluation of results takes about 45 to 60 minutes and there is a charge for this review.

Clear Health Centers.com
203 East 800 South
Salt Lake City, UT 84111
801.875.9292
AdvancingCare@gmail.com

Dr. Alexander Haskell, ND
NPI #1619156113
License #6718543-7100
DEA #MH5824493

 

 

 

 

Clear Health Centers
203 East 800 South
Salt Lake City, UT 84111
801.875.9292
AdvancingCare@gmail.com

 

Dr. Alexander Haskell, ND
NPI #1619156113
License #6718543-7100
DEA #MH5824493