Plasmalogen Therapy

Prevention & Longevity

Plasmalogen Therapy

Prevention & Longevity

Multiple Sclerosis & Plasmalogens

This first section is an introduction to Multiple Sclerosis.

MS is a chronic inflammatory condition of the Central Nervous System (CNS) resulting in widespread demyelination, or damage to the protective covering (myelin sheath) around nerve fibers in the brain, optic nerves and spinal cord.

If this myelin sheath becomes damaged, nerve impulses slow or even stop, leading to neurological problems.

Symptoms vary depending on which sensory and/or motor pathway is affected but the typical symptoms are vision disturbances, extreme fatigue, loss of balance, muscle stiffness, bladder and bowel problems, and partial or complete paralysis.

Multiple sclerosis (MS) is diagnosed on the basis of clinical findings and supporting evidence from various tests, such as magnetic resonance imaging (MRI) of the brain and spinal cord, and cerebrospinal fluid examination.

Inflammation is often the underlying cause with the primary types of medications recommended being non-steroidal anti-inflammatories and short courses of corticosteroids.

If inflammation can be removed, remyelination of nerves may begin.

Myelin Sheath & Plasmalogens

Oligodendrocytes are cells involved with the proliferation, migration, differentiation, and myelination, to produce the insulating sheath surrounding nerves.

Oligodendrocytes are thus the cells which make up the myelin sheath.  Their primary function is to protect the nerves.

This oligodendrocyte sheath is a single cell which can be damaged from inflammation and scarring.

It is thought that he destruction or demyelination is caused by an autoimmune attack but this point of view is being challenged.

Inside oligodendrocyte cells are peroxisomes which are essential for maintaining ‘white matter tracks’ in nerves of the central nervous system.

Peroxisomes are tiny organelles inside cells which synthesize plasmalogens. There are several hundred peroxisomes in a single oligodendrocyte.

The absence of these peroxisomes leads to a deficiency of plasmalogens leading to widespread axonal degeneration and demyelination, plus a strong pro-inflammatory environment, the primary cause of MS.

Ethanolamine is a phospholipid found in myelin, 70-80% of which is composed of plasmalogens.

Thus, if plasmalogen levels decline, demyelination results.

Taking oral plasmalogen directly supports remyelination of nerves and the reduction of MS symptoms.

Multiple Sclerosis & Plasmalogens

Cuprizone is a copper chelating agent and, when ingested or injected, leads to demyelination of nerves, specifically targeting oligodendrocytes, ending with neurodegeneration as we see with MS.

Thus, cuprizone is used in animal studies as a useful tool to study human multiple sclerosis, to investigate ways to slow or reverse the neurodegenerative effects of cuprizone.

Research with mice, one group given cuprizone and the other group cuprizone and a plasmalogen precursor, is summarized.

‘… the orally administrated plasmalogen precursor is capable of restoring plasmalogens in the brain which resulted in remyelination.  Our data suggests that orally bio-available plasmalogens precursors offer a new therapeutic approach for neurodegenerative disorders.’

This study leads us away from the autoimmune hypothesis about MS, to consider both environmental insults and a decline in plasmalogen production by peroxisomes.

Multiple Sclerosis & Plasmalogens

This first section is an introduction to Multiple Sclerosis.

MS is a chronic inflammatory condition of the Central Nervous System (CNS) resulting in widespread demyelination, or damage to the protective covering (myelin sheath) around nerve fibers in the brain, optic nerves and spinal cord.

If this myelin sheath becomes damaged, nerve impulses slow or even stop, leading to neurological problems.

Symptoms vary depending on which sensory and/or motor pathway is affected but the typical symptoms are vision disturbances, extreme fatigue, loss of balance, muscle stiffness, bladder and bowel problems, and partial or complete paralysis.

Multiple sclerosis (MS) is diagnosed on the basis of clinical findings and supporting evidence from various tests, such as magnetic resonance imaging (MRI) of the brain and spinal cord, and cerebrospinal fluid examination.

Inflammation is often the underlying cause with the primary types of medications recommended being non-steroidal anti-inflammatories and short courses of corticosteroids.

If inflammation can be removed, remyelination of nerves may begin.

Myelin Sheath & Plasmalogens

Oligodendrocytes are cells involved with the proliferation, migration, differentiation, and myelination, to produce the insulating sheath surrounding nerves.

Oligodendrocytes are thus the cells which make up the myelin sheath.  Their primary function is to protect the nerves.

This oligodendrocyte sheath is a single cell which can be damaged from inflammation and scarring.

It is thought that he destruction or demyelination is caused by an autoimmune attack but this point of view is being challenged.

Inside oligodendrocyte cells are peroxisomes which are essential for maintaining ‘white matter tracks’ in nerves of the central nervous system.

Peroxisomes are tiny organelles inside cells which synthesize plasmalogens. There are several hundred peroxisomes in a single oligodendrocyte.

The absence of these peroxisomes leads to a deficiency of plasmalogens leading to widespread axonal degeneration and demyelination, plus a strong pro-inflammatory environment, the primary cause of MS.

Ethanolamine is a phospholipid found in myelin, 70-80% of which is composed of plasmalogens.

Thus, if plasmalogen levels decline, demyelination results.

Taking oral plasmalogen directly supports remyelination of nerves and the reduction of MS symptoms.

Multiple Sclerosis & Plasmalogens

Cuprizone is a copper chelating agent and, when ingested or injected, leads to demyelination of nerves, specifically targeting oligodendrocytes, ending with neurodegeneration as we see with MS.

Thus, cuprizone is used in animal studies as a useful tool to study human multiple sclerosis, to investigate ways to slow or reverse the neurodegenerative effects of cuprizone.

Research with mice, one group given cuprizone and the other group cuprizone and a plasmalogen precursor, is summarized.

‘… the orally administrated plasmalogen precursor is capable of restoring plasmalogens in the brain which resulted in remyelination.  Our data suggests that orally bio-available plasmalogens precursors offer a new therapeutic approach for neurodegenerative disorders.’

This study leads us away from the autoimmune hypothesis about MS, to consider both environmental insults and a decline in plasmalogen production by peroxisomes.

Clear Health Centers.com
203 East 800 South
Salt Lake City, UT 84111
801.875.9292
AdvancingCare@gmail.com

Dr. Alexander Haskell, ND
NPI #1619156113
License #6718543-7100
DEA #MH5824493

 

 

 

 

Clear Health Centers
203 East 800 South
Salt Lake City, UT 84111
801.875.9292
AdvancingCare@gmail.com

 

Dr. Alexander Haskell, ND
NPI #1619156113
License #6718543-7100
DEA #MH5824493